Phone: +36 52 512 900 /65764
Dr. András Penyige
University of Debrecen, Faculty of Medicine, Department of Human Genetics
4032 Debrecen, Egyetem tér 1., Hungary
Telephone: +36-52/512-900, 65764
Office: LSB 2.403
Studied biology and chemistry at Lajos Kossuth University of Sciences and Arts Debrecen, 1973-1979. (University thesis: Preparation of embryonic fate map in early developmental mutants of Drosophila melanogaster; prepared at the Biological Research Center of Hungarian Academy of Sciences, Szeged; Institute of Insect Genetics; supervisor: Janos Szabad, Ph.D.,D.Sc.).
Ph.D. (1986). Title of doctorate thesis: Isolation of a streptomycin-containing Park-nucleotide complex from the fermentation broth of S. griseus protoplasts. (Published in Antimicrobial Agents and Chemotherapy)
1979-98, Research associate, Institute of Biology, University Medical School Debrecen,
1998-1999, Research associate, Albert Szentgyörgyi University Szeged, Institute of Medical Biology
1999- Associate Professor, University of Debrecen, Fac. of Medicine, Institute of Human Genetics
1986-1988: at University of Wisconsin, Madison, Dept. of Bacteriology in the laboratory of Prof. J.C. Ensign as a post-doctoral fellow.
1992-1993: Universite de Liege, Centre d,Ingeniere des Proteins, Belgium
1994-1995: National Food Research Institute, Biomolecular Transfunction Laboratory, Tsukuba, Japan, research associate.
2003: SGM Fellowship, University of East Anglia, School of Biological Sciences, Norwich, UK,
2004-2005: Lahey Hospital and Medical Center, Burlington, MA. USA
Hungarian Society of Microbiology
European Society of Human Genetics
Hungarian Society of Human Genetics
Acknowledgment of the Minister of Health for excellent teaching activities (1986, Budapest).
Fields of interest:
1. Investigation of the mode of action of b-lactam antibiotics, the function and biochemical characterization of of the b-lactamase gene in Streptomyces strains. Testing of new b-lactam compounds. Study of regulation and induction of autolytic enzymes in Streptomyces strains.
2. Study of the regulation of differentiation, antibiotic production and spore formation in Streptomyces griseus, including: the mechanism of action of A-factor, GTP-binding proteins, the physiological role of protein ADP-ribosylation and Ca2+-binding proteins in Streptomyces.
3. Study of the role of G-proteins during aging in human lymphocytes and neutrophyl granulocytes.
4. Genetic association studies in complex human diseases (COPD, IBD, exome sequence analysis).
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