Study the role of miRNAs in the carcionogenic action of estrogen molecules
Participants: Melinda Szilágyi-Bónizs, Bálint Nagy, Éva Márton, Katalin Trefán
MicroRNAs (miRNAs) are small non-coding RNA molecules, which play important role in posttranscriptional gene regulation. They are involved in the regulation of several biological processes including development, differentiation, apoptosis or proliferation. MicroRNAs are also present in body fluids due to their active transport from the cells that suggest their role in cell-cell communication. MiRNAs has become the focus of interest in cancer studies recently due to the fact that these molecules proved to have various roles in oncogenesis as oncomirs or tumor suppressors. The carcinogenic action of estrogen molecules is a well-known phenomenon in breast cancer, however, limited information is available about their contribution to the development of ovarian cancer. In our studies we would like to shed light on the role of miRNAs in the carcinogenic effect of estrogen molecules in human epithelial ovarian cell cultures.
