Monoclonal antibody proteomics
Members: Laszlo Takacs, Ilona Tornyi, Biosystems International Ltd.: József Lázár, Lora Szilágyi, Anna Gáll-Debreczeni, Zsombor Lestár
One form of proteomics research is affinity proteomics, monoclonal antibody proteomics is one form of affinity proteomics.
We focus on applied translational research; our goals are the development of blood tests that aid cancer diagnosis and the understanding of the underlying molecular mechanism. To achieve the goal our laboratory, in collaboration with Biosystems International Ltd., established the epitome profiling technology. We prepared monoclonal antibody libraries directed against natural epitopes of the human blood plasma, we then applied the libraries onto biochips (Randox Ltd. Northern Ireland). We profile close to 300 epitopes of about 100 proteins. With the aid of machine learning algorithms we develop multivariate index assays for the early detection of breast, colon, ovarian and lung cancers. The panels run on the Evidence Investigator platform and on the classic 96-well ELISA plates. The latter lung cancer test (QPLC96w) is sold by BSI, the university laboratory is involved in research addressed towards the understanding of the molecular basis of the phenomenon.
We published 11 peer reviewed scientific papers on the topic (papers
), and BSI filed >10 patents (patents